Welcome!

I recently defended my PhD at the Department of Systems Biology at Columbia University. My dissertation research focused on developing statistical tools and mathematical models to profile the T cell receptor (TCR) immune repertoire. I analyzed data from high throughput sequencing of the CDR3 region on the TCR to characterize repertoire diversity and inter-tissue divergence, and to develop a general mathematical framework for describing TCR populations. I have worked on projects looking at:
  • The distribution and maintenance of na├»ve T cells in lymph nodes
  • Diversity and divergence of T cell repertoires associated with glioma diagnosis and
  • The size and diversity of the human alloresponse.

    This website is a fun side project that I've been putting togethere bit by bit. The first application I've developed is a blog that can be reached from the menubar. The projects section currently hosts a simple tool built in javascript for translating and reverse complimenting nucleotide sequences. I hope to host many more projects in the future.

RESUME

boris-grinshpun-469b8420 <— LinkedIn

github.com/bgrinshpun <— GitHub



Recently minted PhD from Columbia University Department of Systems Biology with a strong background in applied mathematics and statistics, and expertise in T cell receptor repertoire profiling. Looking for industry jobs in the biotechnology sector. Particular interest in data analysis and tool development for immunotherapy applications and cancer research. Interested in working as part of a research team, developing further scientific and research expertise, and building career and leadership skills.



Columbia UniversityPh.D., Systems BiologyNew York, NY
2011 – 2017
Columbia UniversityB.S. Applied MathematicsNew York, NY
2006 – 2010
Stuyvesant High SchoolNew York, NY
2002 – 2006


Research Assistant, Columbia University
2011 – 2017, New York, NY
  • Built mathematical models to characterize the T cell receptor repertoire from human tissues in three separate projects focusing on: 1. Healthy lymphoid tissues 2. Gliomas and 3. Alloreactivity
Undergraduate Researcher, Columbia University
2008 – 2010, New York, NY
  • Assisted in implementation and development of a statistical model to study the relationship between structure and function in small gene regulatory networks
Undergraduate Researcher, Columbia University
2008 – 2010, New York, NY
  • Helped to develop a mathematical model to study contrast controlled adaptation in human pattern vision


*Co-first author

  1. Quantifying the Size and Diversity of the Human Alloresponse via High-Throughput T Cell Receptor Sequencing. Susan DeWolf*, Boris Grinshpun*, et.al.  In Preparation (2017)
  2. Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites. Joseph J.C. Thome*, Boris Grinshpun*, Brahma V. Kumar, Masaru Kubota, Yoshiaki Ohmura, Harvey Lerner, Gregory D. Sempowski, Yufeng Shen, Donna L. Farber  Science Immunology (2016)
  3. Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire. Jennifer Sims, Boris Grinshpun, Yaping Feng, Timothy H. Ung, Justin A. Niera, Jorge L. Samanamud, Peter Canoll, Jeffrey N. Bruce, Peter Sims, Yufeng Shen  PNAS (2016)
  4. Spatial map of human T cell compartmentalization and maintenance over decades of life. Joseph J.C. Thome, Naomi Yudanin, Yoshiaki Ohmura, Masaru Kubota, Boris Grinshpun, Taheri Sathaliyawala, Tomoaki Kato, Harvey Lerner, Yufeng Shen, Donna L. Farber  Cell (2014)
  5. Analyzing T cell repertoire diversity by high-throughput sequencing. Boris Grinshpun, Jennifer Sims, Peter Canoll, Jeffrey N. Bruce, Peter Sims, Yufeng Shen  GlobalSIP/IEEE Conference (2013)
  6. Statistical method for revealing form-function relations in biological networks. Andrew Mugler, Boris Grinshpun, Riley Franks, Chris H. Wiggins  PNAS (2010)


Operating Systems: Unix/Bash, Linux, Windows & Mac

Software Tools: Microsoft{Office, Excel, Powerpoint}, Git, Django, BWA, SAMtools, BLAST, Inkscape

Programming: R, Python, Perl, MATLAB, LaTeX, HTML, Jinja

Languages: English, Russian



CoOrganizer for the Columbia Microbiome GroupOrganized meetings, Invited speakers, Maintained website2015 – 2017
Columbia Systems Biology Seminar OrganizerOrganized meetings, Invited speakers2013 – 2015
Intel ISEF 2015 Grand Awards JudgeJudged high school finalists at Intel Science Fair2015
Society for Industrial and Applied Mathematics, Chapter PresidentOrganized talks, Organized and participated in MATLAB tutoring sessions2009 – 2010